The adjective little means not much or hardly any. It has a negative meaning.

• There is little hope of his recovery. (= He is not likely to recover.)
• She showed little concern for her old parents.

A little means some, but not much.

• There is a little hope of his recovery. (= He may possible recover.)
• A little knowledge is a dangerous thing.

The little means not much, but all of that much.

• The little information we had was not quite reliable.
• The little influence that he has, he uses to the best advantage.

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